Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas.

  title={Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas.},
  author={Yan Ma and Steven Fiering and Candice Black and Xi Liu and Ziqiang Yuan and Vincent A. Memoli and David J Robbins and Heather A Bentley and Gregory J. Tsongalis and Eugene Demidenko and Sarah J. Freemantle and Ethan Dmitrovsky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 10},
Cyclin E is a critical G(1)-S cell cycle regulator aberrantly expressed in bronchial premalignancy and lung cancer. Cyclin E expression negatively affects lung cancer prognosis. Its role in lung carcinogenesis was explored. Retroviral cyclin E transduction promoted pulmonary epithelial cell growth, and small interfering RNA targeting of cyclin E repressed this growth. Murine transgenic lines were engineered to mimic aberrant cyclin E expression in the lung. Wild-type and proteasome degradation… CONTINUE READING


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