Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas.

@article{Ma2007TransgenicCE,
  title={Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas.},
  author={Yan Ma and Steven Fiering and Candice Black and Xi Liu and Ziqiang Yuan and Vincent A. Memoli and David J Robbins and Heather A Bentley and Gregory J. Tsongalis and Eugene Demidenko and Sarah J. Freemantle and Ethan Dmitrovsky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 10},
  pages={4089-94}
}
Cyclin E is a critical G(1)-S cell cycle regulator aberrantly expressed in bronchial premalignancy and lung cancer. Cyclin E expression negatively affects lung cancer prognosis. Its role in lung carcinogenesis was explored. Retroviral cyclin E transduction promoted pulmonary epithelial cell growth, and small interfering RNA targeting of cyclin E repressed this growth. Murine transgenic lines were engineered to mimic aberrant cyclin E expression in the lung. Wild-type and proteasome degradation… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Similar Papers

Loading similar papers…