Transgenic animal models in toxicology: historical perspectives and future outlook.

@article{Boverhof2011TransgenicAM,
  title={Transgenic animal models in toxicology: historical perspectives and future outlook.},
  author={D. R. Boverhof and Mark Chamberlain and Clifford R. Elcombe and Frank J. Gonzalez and Robert H Heflich and Lya G. Hern{\'a}ndez and Abigail C Jacobs and David Jacobson-Kram and Mirjam Luijten and Adriana Maggi and Mugimane G. Manjanatha and Jan van Benthem and B. Bhaskar Gollapudi},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2011},
  volume={121 2},
  pages={
          207-33
        }
}
Transgenic animal models are powerful tools for developing a more detailed understanding on the roles of specific genes in biological pathways and systems. Applications of these models have been made within the field of toxicology, most notably for the screening of mutagenic and carcinogenic potential and for the characterization of toxic mechanisms of action. It has long been a goal of research toxicologists to use the data from these models to refine hazard identification and characterization… 
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