Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial function.

Abstract

Rat models of hypertension, eg, spontaneously hypertensive stroke-prone rats (SHRSP), display reduced angiotensin-converting enzyme 2 (ACE2) mRNA and protein expression compared with control animals. The aim of this study was to investigate the role of ACE2 in the pathogenesis of hypertension in these models. Therefore, we generated transgenic rats on a… (More)
DOI: 10.1161/HYPERTENSIONAHA.108.114322

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@article{Rentzsch2008TransgenicAE, title={Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial function.}, author={Brit Rentzsch and Mihail Todiras and Radu G. Iliescu and Elena Popova and Luciana Aparecida Campos and Marilene Luzia Oliveira and Ovidiu Constantin Baltatu and Robson Augusto Souza Santos and Michael Bader}, journal={Hypertension}, year={2008}, volume={52 5}, pages={967-73} }