Transgenic alteration of Toll immune pathway in the female mosquito Aedes aegypti.

  title={Transgenic alteration of Toll immune pathway in the female mosquito Aedes aegypti.},
  author={Guowu Bian and Sang Woon Shin and Hyang-Mi Cheon and Vladimir A. Kokoza and Alexander S. Raikhel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 38},
Reverse genetics is a powerful tool for understanding gene functions and their interactions in the mosquito innate immunity. We took the transgenic approach, in combination with the RNA interference (RNAi) technique, to elucidate the role of mosquito REL1, a homolog of Drosophila Dorsal, in regulation of Toll immune pathway in the mosquito Aedes aegypti. By transforming the mosquitoes with DeltaREL1-A or a double-stranded RNA construct of REL1 driven by the female fat body-specific vitellogenin… CONTINUE READING

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