Transgenic activation of the kallikrein‐kinin system inhibits intramyocardial inflammation, endothelial dysfunction, and oxidative stress in experimental diabetic cardiomyopathy

@article{Tschope2005TransgenicAO,
  title={Transgenic activation of the kallikrein‐kinin system inhibits intramyocardial inflammation, endothelial dysfunction, and oxidative stress in experimental diabetic cardiomyopathy},
  author={C. Tschöpe and T. Walther and F. Escher and F. Spillmann and Jing Du and C. Altmann and I. Schimke and M. Bader and C. S{\'a}nchez‐Ferrer and H. Schultheiss and And Michel Noutsias},
  journal={The FASEB Journal},
  year={2005},
  volume={19}
}
The mechanisms contributing to diabetic cardiomyopathy, as well as the protective pathways of the kallikrein‐kinin‐system (KKS), are incompletely understood. In a kallikrein‐overexpressing rat model of streptozotocin (STZ)‐induced diabetic cardiomyopathy, we investigated the involvement of inflammatory pathways, endothelial dysfunction, and oxidative stress. Six weeks after STZ injection, impairment of left ventricular (LV) function parameters measured by a Millar‐tip catheter (peak LV systolic… Expand
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