Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice.

@article{Sidman1992TransgenicTC,
  title={Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice.},
  author={Charles L. Sidman and Jason D Marshall and Harald von Boehmer},
  journal={European journal of immunology},
  year={1992},
  volume={22 2},
  pages={
          499-504
        }
}
To investigate the role of T cell receptor (TcR) expression and interactions in development of lymphoproliferation and autoimmunity in lpr and gld mutant mice, and to determine whether these autoimmune mutations affect T cell selection and repertoire formation, we generated mice homozygous for either the gld or the lpr mutation and containing TcR alpha/beta transgenes (Von Boehmer, H., Annu. Rev. Immunol. 1990. 8: 531) specific for the male (H-Y) antigen in the context of H-2Db. Four main… CONTINUE READING
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