Transgenic Strategies in Autonomic Research

  title={Transgenic Strategies in Autonomic Research},
  author={Kazuto Kobayashi and Toshiharu Nagatsu},
Publisher Summary This chapter describes the strategy of immunotoxin-mediated cell targeting (IMCT) and its use to generate a transgenic mouse model for autonomic neuropathy (AN) derived from disruption of the peripheral catecholaminergic cell types. In the strategy of IMCT, transgenic mice are generated that express human interleukin-2 receptor α-subunit (IL-2Rα) under the control of a cell type-specific gene promoter. IMCT was used to generate an animal model that exhibits autonomic failure… CONTINUE READING