Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency

Abstract

De novo mutations arise mostly in the male germline and may contribute to adverse health outcomes in subsequent generations. Traditional methods for assessing the induction of germ cell mutations require the use of large numbers of animals, making them impractical. As such, germ cell mutagenicity is rarely assessed during chemical testing and risk… (More)
DOI: 10.3791/51576

8 Figures and Tables

Topics

  • Presentations referencing similar topics