Transgenic Rats Carrying Human c‐Ha‐ras Proto‐oncogene Are Highly Susceptible to N‐Nitrosomethylbenzylamine Induction of Esophageal Tumorigenesis

@inproceedings{Asamoto2002TransgenicRC,
  title={Transgenic Rats Carrying Human c‐Ha‐ras Proto‐oncogene Are Highly Susceptible to N‐Nitrosomethylbenzylamine Induction of Esophageal Tumorigenesis},
  author={Makoto Asamoto and Hiroyasu Toriyama‐Baba and Takamasa Ohnishi and Akihiro Naito and Tomonori Ota and Akira Ando and Takahiro Ochiya and Hiroyuki Tsuda},
  booktitle={Japanese journal of cancer research : Gann},
  year={2002}
}
A transgenic rat line carrying three copies of the human c-Ha-ras proto-oncogene, including its own promoter region, has been established in our laboratory (Hras128 rats), and shown to be highly susceptible to induction of mammary and urinary bladder tumors. Mutation analysis of induced lesions indicated the majority to contain some but not all cells with transgene mutation. In the present study, the susceptibility of Hras128 rats to N-nitrosomethylbenzylamine (NMBA) induction of esophageal… CONTINUE READING