Transgenic Overexpression of the Type I Isoform of Neuregulin 1 Affects Working Memory and Hippocampal Oscillations but not Long-term Potentiation

@inproceedings{Deakin2012TransgenicOO,
  title={Transgenic Overexpression of the Type I Isoform of Neuregulin 1 Affects Working Memory and Hippocampal Oscillations but not Long-term Potentiation},
  author={Inga H. Deakin and Wiebke Nissen and Amanda J. Law and Tracy Lane and Riam Kanso and Markus H. Schwab and Klaus-Armin Nave and Karri P Lamsa and Ole Paulsen and D. M. Bannerman and Paul J. Harrison},
  booktitle={Cerebral cortex},
  year={2012}
}
Neuregulin 1 (NRG1) is a growth factor involved in neurodevelopment and plasticity. It is a schizophrenia candidate gene, and hippocampal expression of the NRG1 type I isoform is increased in the disorder. We have studied transgenic mice overexpressing NRG1 type I (NRG1(tg-type I)) and their wild-type littermates and measured hippocampal electrophysiological and behavioral phenotypes. Young NRG1(tg-type I) mice showed normal memory performance, but in older NRG1(tg-type I) mice, hippocampus… CONTINUE READING

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Neuregulin-1 impairs the long-term depression of hippocampal inhibitory synapses by facilitating the degradation of endocannabinoid 2-AG.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2013
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