Transgenic Mice with a Reduced Core Body Temperature Have an Increased Life Span

@article{Conti2006TransgenicMW,
  title={Transgenic Mice with a Reduced Core Body Temperature Have an Increased Life Span},
  author={B. Conti and M. S{\'a}nchez-Alavez and R. Winsky-Sommerer and M. C. Morale and J. Lucero and S. Brownell and V. Fabre and S. Huitr{\'o}n-Res{\'e}ndiz and S. Henriksen and E. Zorrilla and L. de Lecea and T. B{\'a}rtfai},
  journal={Science},
  year={2006},
  volume={314},
  pages={825 - 828}
}
  • B. Conti, M. Sánchez-Alavez, +9 authors T. Bártfai
  • Published 2006
  • Biology, Medicine
  • Science
  • Reduction of core body temperature has been proposed to contribute to the increased life span and the antiaging effects conferred by calorie restriction (CR). Validation of this hypothesis has been difficult in homeotherms, primarily due to a lack of experimental models. We report that transgenic mice engineered to overexpress the uncoupling protein 2 in hypocretin neurons (Hcrt-UCP2) have elevated hypothalamic temperature. The effects of local temperature elevation on the central thermostat… CONTINUE READING
    300 Citations

    Topics from this paper

    Cooling Core Body Temperature May Slow Down Neurodegeneration
    • 15
    Effect of long-term caloric restriction on oxygen consumption and body temperature in two different strains of mice
    • 58
    Metabolic adaptation to calorie restriction
    • PDF
    Thermoregulation in mice exhibits genetic variability early in senescence
    • 7
    Gross energy metabolism in mice under late onset, short term caloric restriction
    • 19
    • PDF

    References

    SHOWING 1-10 OF 74 REFERENCES
    Analysis of energy expenditure at different ambient temperatures in mice lacking DGAT1.
    • 67
    • PDF
    Are mice calorically restricted in nature?
    • 56
    • PDF
    Orexin-A Regulates Body Temperature in Coordination with Arousal Status
    • 134
    Effects of temperature on the life span, vitality and fine structure of Drosophila melanogaster
    • 306