Transgenic Mice with a Reduced Core Body Temperature Have an Increased Life Span

@article{Conti2006TransgenicMW,
  title={Transgenic Mice with a Reduced Core Body Temperature Have an Increased Life Span},
  author={Bruno Conti and Manuel S{\'a}nchez-Alavez and Raphaelle Winsky-Sommerer and Maria Concetta Morale and Jacinta D. Lucero and Sara E. Brownell and Véronique Fabre and Salvador Huitrón-Reséndiz and Steven J. Henriksen and Eric P Zorrilla and Luis de Lecea and Tam{\'a}s B{\'a}rtfai},
  journal={Science},
  year={2006},
  volume={314},
  pages={825 - 828}
}
Reduction of core body temperature has been proposed to contribute to the increased life span and the antiaging effects conferred by calorie restriction (CR). Validation of this hypothesis has been difficult in homeotherms, primarily due to a lack of experimental models. We report that transgenic mice engineered to overexpress the uncoupling protein 2 in hypocretin neurons (Hcrt-UCP2) have elevated hypothalamic temperature. The effects of local temperature elevation on the central thermostat… 
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