Transgenic GATA-4 expression induces adrenocortical tumorigenesis in C57Bl/6 mice.

  title={Transgenic GATA-4 expression induces adrenocortical tumorigenesis in C57Bl/6 mice.},
  author={Marcin Chruściel and Susanna Vuorenoja and Bidut Prava Mohanty and Adolfo Rivero-M{\"u}ller and Xiangdong Li and Jorma Toppari and I lpo Huhtaniemi and Nafis Rahman},
  journal={Journal of cell science},
  volume={126 Pt 8},
A link between elevated luteinizing hormone (LH) levels, GATA-4 and LH receptor (LHCGR) expression and gonadotropin-dependent adrenocortical tumorigenesis in humans and mice has been shown. To assess the mechanistic tumorigenic interrelationships between these factors, we transgenically expressed Gata4 under the 21-hydroxylase promoter (Cyp21a1, 21-OH) in C57Bl/6N mice. There was a gradual age-dependent increase of GATA-4 expression only in 21-OH-GATA-4 (TG) female adrenals, in association with… CONTINUE READING
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