Transgenic Fluorescent Plasmodium cynomolgi Liver Stages Enable Live Imaging and Purification of Malaria Hypnozoite-Forms

@inproceedings{Wel2013TransgenicFP,
  title={Transgenic Fluorescent Plasmodium cynomolgi Liver Stages Enable Live Imaging and Purification of Malaria Hypnozoite-Forms},
  author={Annemarie Voorberg-van der Wel and Anne-Marie Zeeman and Sandra M. van Amsterdam and Alexander van den Berg and Els J. Klooster and Shiroh Iwanaga and Chris J Janse and Geert-Jan J. van Gemert and Robert W. Sauerwein and Niels Beenhakker and Gerrit Koopman and Alan W. Thomas and Clemens H. M. Kocken},
  booktitle={PloS one},
  year={2013}
}

• Annemarie Voorberg-van der Wel, Anne-Marie Zeeman, +10 authors Clemens H. M. Kocken
• Published 2013 in PloS one
• DOI:10.1371/journal.pone.0054888

A major challenge for strategies to combat the human malaria parasite Plasmodium vivax is the presence of hypnozoites in the liver. These dormant forms can cause renewed clinical disease after reactivation through unknown mechanisms. The closely related non-human primate malaria P. cynomolgi is a frequently used model for studying hypnozoite-induced relapses. Here we report the generation of the first transgenic P. cynomolgi parasites that stably express fluorescent markers in liver stages by… CONTINUE READING

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