Transgenic CHD1L Expression in Mouse Induces Spontaneous Tumors

  title={Transgenic CHD1L Expression in Mouse Induces Spontaneous Tumors},
  author={Muhan Chen and Jian-Dong Huang and Liang Hu and Bo-jian Zheng and Leilei Chen and Sze Lan Tsang and Xinyuan Guan},
  booktitle={PloS one},
BACKGROUND Amplification of 1q21 is the most frequent genetic alteration in hepatocellular carcinoma (HCC), which was detected in 58-78% of primary HCC cases by comparative genomic hybridization (CGH). Using chromosome microdissection/hybrid selection approach we recently isolated a candidate oncogene CHD1L from 1q21 region. Our previous study has demonstrated that CHD1L had strong oncogenic ability, which could be effectively suppressed by siRNA against CHD1L. The molecular mechanism of CHD1L… CONTINUE READING
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