Transgenerational transmission and modification of pathological traits induced by prenatal immune activation

@article{WeberStadlbauer2017TransgenerationalTA,
  title={Transgenerational transmission and modification of pathological traits induced by prenatal immune activation},
  author={Ulrike Weber-Stadlbauer and Juliet Richetto and Marie Ana{\"i}s Labouesse and Johannes Bohacek and Isabelle M Mansuy and Urs Meyer},
  journal={Molecular Psychiatry},
  year={2017},
  volume={22},
  pages={102-112}
}
Prenatal exposure to infectious or inflammatory insults is increasingly recognized to contribute to the etiology of psychiatric disorders with neurodevelopmental components, including schizophrenia, autism and bipolar disorder. It remains unknown, however, if such immune-mediated brain anomalies can be transmitted to subsequent generations. Using an established mouse model of prenatal immune activation by the viral mimetic poly(I:C), we show that reduced sociability and increased cued fear… CONTINUE READING
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