Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress.

@article{Rodgers2015TransgenerationalEP,
  title={Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress.},
  author={Ali B. Rodgers and Christopher P. Morgan and Nicolae Adrian Leu and Tracy L Bale},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 44},
  pages={13699-704}
}
Epigenetic signatures in germ cells, capable of both responding to the parental environment and shaping offspring neurodevelopment, are uniquely positioned to mediate transgenerational outcomes. However, molecular mechanisms by which these marks may communicate experience-dependent information across generations are currently unknown. In our model of chronic paternal stress, we previously identified nine microRNAs (miRs) that were increased in the sperm of stressed sires and associated with… CONTINUE READING