Transgenerational epigenetic inheritance in health and disease.

  title={Transgenerational epigenetic inheritance in health and disease.},
  author={Nadia C. Whitelaw and Emma Whitelaw},
  journal={Current opinion in genetics & development},
  volume={18 3},
Over the past century, patterns of phenotypic inheritance have been observed that are not easily rationalised by Mendel's rules of inheritance. Now that we have begun to understand more about non-DNA based, or 'epigenetic', control of phenotype at the molecular level, the idea that the transgenerational inheritance of these epigenetic states could explain non-Mendelian patterns of inheritance has become attractive. There is a growing body of evidence that abnormal epigenetic states, termed… CONTINUE READING

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