Transgenerational epigenetic effects of the endocrine disruptor vinclozolin on pregnancies and female adult onset disease.

@article{Nilsson2008TransgenerationalEE,
  title={Transgenerational epigenetic effects of the endocrine disruptor vinclozolin on pregnancies and female adult onset disease.},
  author={Eric E Nilsson and Matthew D. Anway and Jacob Stanfield and Michael K. Skinner},
  journal={Reproduction},
  year={2008},
  volume={135 5},
  pages={713-21}
}
Endocrine disruptor exposure during gonadal sex determination was previously found to induce male rat adult onset transgenerational disease (F1-F4 generation), and this was associated with an alteration in the epigenetic (i.e., DNA methylation) programming of the male germ line. The current study was designed to characterize the transgenerational disease phenotypes of the female adult offspring. Pregnant rats (F0 generation) were treated transiently with vinclozolin (i.e., fungicide with anti… CONTINUE READING