Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life

  title={Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life},
  author={RC Painter and Clive Osmond and Peter D. Gluckman and Mark A. Hanson and Diw Phillips and T Roseboom},
  journal={BJOG: An International Journal of Obstetrics \& Gynaecology},
OBJECTIVE Maternal undernutrition during gestation is associated with increased metabolic and cardiovascular disease in the offspring. [] Key MethodDESIGN Historical cohort study. SETTING Interview during a clinic or home visit or by telephone. POPULATION Men and women born in the Wilhelmina Gasthuis in Amsterdam between November 1943 and February 1947.
Transgenerational effects of prenatal exposure to the 1944–45 Dutch famine
It is found that maternal under‐nutrition during gestation is associated with increased metabolic and cardiovascular disease in the offspring and increased neonatal adiposity among the grandchildren of women who had been undernourished during pregnancy.
Prenatal high‐fat diet alters placental morphology, nutrient transporter expression, and mtorc1 signaling in rat
This study aimed to determine how the rat placenta and fetus respond to maternal high‐fat (HF) diet during gestation and to identify the possible mechanisms.
Childhood central adiposity at ages 5 and 9 shows consistent relationship with that of the maternal grandmother but not other grandparents
The importance of a life course approach to childhood obesity has been emphasized, but few studies can prospectively investigate relationships in three‐generation families and the need for more research into this approach is emphasized.
The Role of Epigenetic Regulation in the Development of Obesity: A Comprehensive Review
Ovine and murine models show that maternal overnutrition and maternal undernutrition are implicated in epigenetic dysregulation of endogenous energy-balance mechanisms.
Transgenerational effects of periconception cadmium and mercury co-administration to mice on indices of chronic disease in offspring at maturity
This work presents the results of a two-year study of the impact of temperature and management techniques on the behaviour of mice in the context of warming and drought in the Northern Hemisphere.
From Epidemiology to Epigenetics: Evidence for the Importance of Nutrition to Optimal Health Development Across the Life Course
This book presents a meta-anatomy of the immune system, which examines the immune response to foods, herbs and spices over a long period of time and reveals patterns that can be traced back to hunter-gatherer times.
Transgenerational Effects of Childhood Conditions on Third Generation Health and Education Outcomes
This paper examines the extent to which pre-puberty nutritional conditions in one generation affect productivity-related outcomes in later generations. Recent findings from the biological literature
Metabolic programming in early life in humans
While current preventive strategies for cardio-metabolic disease focus on high-risk individuals in mid-life, DOHaD concepts offer a ‘primordial’ preventive strategy to reduce disease in future generations by improving fetal and infant development.


Intergenerational effects of preterm birth and reduced intrauterine growth: a population‐based study of Swedish mother–offspring pairs
The intergenerational effects of preterm birth and reduced intrauterine growth are estimated to affect the children of both parents and the generations to come.
Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats.
  • A. Drake, B. Walker, J. Seckl
  • Biology, Medicine
    American journal of physiology. Regulatory, integrative and comparative physiology
  • 2005
The persistence of such programming effects through several generations, transmitted by either maternal or paternal lines, indicates the potential importance of epigenetic factors in the intergenerational inheritance of the "programming phenotype" and provides a basis for the inherited association between low birth weight and cardiovascular risk factors.
The fetal origins of coronary heart disease.
  • D. Barker
  • Medicine
    Acta paediatrica (Oslo, Norway : 1992). Supplement
  • 1997
Animal studies have shown that undernutrition before birth programmes persisting changes in a range of metabolic, physiological and structural parameters are persisting and humans are beginning to understand something of the mechanisms underlying these associations.
Obesity in young men after famine exposure in utero and early infancy.
Testing the hypothesis that prenatal and early postnatal nutrition determines subsequent obesity found that exposure during the last trimester of pregnancy and the first months of life is consistent with the inference that nutritional deprivation affected a critical period of development for adipose-tissue cellularity.
Is birth weight related to later glucose and insulin metabolism?—a systematic review
Aim To determine the relationship of birth weight to later glucose and insulin metabolism and to establish a cause-and-effect relationship between birth weight and metabolism.
Plasma lipid profiles in adults after prenatal exposure to the Dutch famine.
It is suggested that maternal malnutrition during early gestation may program lipid metabolism without affecting size at birth, and an atherogenic lipid profile might be linked to a transition from poor maternal nutrition in early gestation to adequate nutrition later on.
Sex-specific, male-line transgenerational responses in humans
It is concluded that sex-specific, male-line transgenerational responses exist in humans and hypothesise that these transmissions are mediated by the sex chromosomes, X and Y and add an entirely new dimension to the study of gene–environment interactions in development and health.
Anthropometric measures in middle age after exposure to famine during gestation: evidence from the Dutch famine.
Reduced food availability may lead to increased adiposity later in life in female offspring, and exposure to reduced rations was associated with increased weight and greater indexes of fat deposition at several tissue sites in women but not in men.
Nongenomic transmission across generations of maternal behavior and stress responses in the rat.
Results of cross-fostering studies reported here indicate that variations in maternal care can serve as the basis for a nongenomic behavioral transmission of individual differences in stress reactivity across generations.