Transgenerational Propagation and Quantitative Maintenance of Paternal Centromeres Depends on Cid/Cenp-A Presence in Drosophila Sperm

@inproceedings{Raychaudhuri2012TransgenerationalPA,
  title={Transgenerational Propagation and Quantitative Maintenance of Paternal Centromeres Depends on Cid/Cenp-A Presence in Drosophila Sperm},
  author={Nitika Raychaudhuri and Raphaelle Dubruille and Guillermo A. Orsi and Homayoun C. Bagheri and Benjamin Loppin and Christian F Lehner},
  booktitle={PLoS biology},
  year={2012}
}
In Drosophila melanogaster, as in many animal and plant species, centromere identity is specified epigenetically. In proliferating cells, a centromere-specific histone H3 variant (CenH3), named Cid in Drosophila and Cenp-A in humans, is a crucial component of the epigenetic centromere mark. Hence, maintenance of the amount and chromosomal location of CenH3 during mitotic proliferation is important. Interestingly, CenH3 may have different roles during meiosis and the onset of embryogenesis. In… CONTINUE READING

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