Transgenerational Inheritance of Paternal Neurobehavioral Phenotypes: Stress, Addiction, Ageing and Metabolism

@article{Yuan2015TransgenerationalIO,
  title={Transgenerational Inheritance of Paternal Neurobehavioral Phenotypes: Stress, Addiction, Ageing and Metabolism},
  author={Ti-fei Yuan and Ang Li and Xin Sun and Huan Ouyang and Carlos Campos and Nuno Barbosa Rocha and {\'O}scar Arias-Carri{\'o}n and Sergio Machado and Gonglin Hou and Kwok-fai So},
  journal={Molecular Neurobiology},
  year={2015},
  volume={53},
  pages={6367-6376}
}
  • T. Yuan, Ang Li, K. So
  • Published 1 November 2016
  • Biology, Psychology
  • Molecular Neurobiology
Epigenetic modulation is found to get involved in multiple neurobehavioral processes. It is believed that different types of environmental stimuli could alter the epigenome of the whole brain or related neural circuits, subsequently contributing to the long-lasting neural plasticity of certain behavioral phenotypes. While the maternal influence on the health of offsprings has been long recognized, recent findings highlight an alternative way for neurobehavioral phenotypes to be passed on to the… 
Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function
Addictions are highly heritable disorders, with heritability estimates ranging from 39% to 72%. Multiple studies suggest a link between paternal drug abuse and addiction in their children. However,
Prenatal programming of stress responsiveness and behaviours: Progress and perspectives
TLDR
This review will focus on the latest research, bridging human and pre‐clinical studies, and will highlight some of the limitations, challenges and gaps that exist in the field.
Multi-, Inter-, and Transgenerational Effects of Drugs of Abuse on Behavior.
TLDR
This chapter in current topics in behavioral neurogenomics examines the evidence for the presence of behavioral phenotypes and, in particular, the varied and often opposite behavioral responses observed with protocol shifts.
Subfertility of Offspring and Transgenerational Transmission of Splenic Transcriptome Induced by Lipopolysaccharide in Hens
TLDR
It is discovered that maternal stimulation could reduce the immunity of laying hens and their offspring, resulting in a decrease in egg-laying rate, which could be regulated by the transcriptome's transgenerational transmission.
The link among microbiota, epigenetics, and disease development
TLDR
The present review illustrates the roles of diet, microbiome, and epigenetics in the induction of several chronic diseases and discusses the application of epigenetic data to develop diagnostic biomarkers and therapeutics and evaluate their safety for patients.
An Overview of the Heterogeneity of Major Depressive Disorder: Current Knowledge and Future Prospective
TLDR
It is important to understand the modern pathogenetic hypotheses and mechanisms, and possibly try to shift from the traditional approaches in depression therapy, to develop multitargeted therapies that hold much promise as compared to the conventional monoamine based treatment.
Male Obesity Associated Gonadal Dysfunction and the Role of Bariatric Surgery
TLDR
The pathophysiology of obesity on the male reproductive system and emerging evidence regarding the potential role of bariatric surgery as treatment of male obesity-associated gonadal dysfunction are summarized.
...
...

References

SHOWING 1-10 OF 119 REFERENCES
Epigenetic transgenerational inheritance of altered stress responses
TLDR
It is found that a single exposure to a common-use fungicide three generations removed alters the physiology, behavior, metabolic activity, and transcriptome in discrete brain nuclei in descendant males, causing them to respond differently to chronic restraint stress.
Lifetime stress experience: transgenerational epigenetics and germ cell programming
  • T. Bale
  • Psychology, Biology
    Dialogues in clinical neuroscience
  • 2014
TLDR
Animal models of parental stress have examined relevant offspring phenotypes and transgenerational outcomes, and provided unique insight into the germ cell epigenetic changes associated with disruptions in neurodevelopment.
Transgenerational Epigenetic Programming of the Brain Transcriptome and Anxiety Behavior
TLDR
It is demonstrated that an embryonic exposure to an environmental compound appears to promote a reprogramming of brain development that correlates with transgenerational sex-specific alterations in the brain transcriptomes and behavior.
Epigenetic Transmission of the Impact of Early Stress Across Generations
Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals
TLDR
This study uniquely revealed that prediabetes can be inherited transgenerationally through the mammalian germ line by an epigenetic mechanism, and increases the susceptibility to diabetes in offspring through gametic epigenetic alterations.
Transgenerational neuroendocrine disruption of reproduction
TLDR
Current understanding of the epigenetic mechanisms that underlie sexual differentiation of reproductive neuroendocrine systems in mammals is discussed and the literature on transgenerational epigenetic effects of representative EDCs: vinclozolin, diethylstilbesterol, bisphenol A and polychlorinated biphenyls is summarized.
Epigenetic mechanisms of depression and antidepressant action.
TLDR
Recent advances in understanding of the epigenetic regulation of stress-related disorders are discussed and the hypothesis that aberrations in chromatin remodeling and subsequent effects on gene expression within limbic brain regions contribute to the pathogenesis of depression is supported.
Epigenetic mechanisms of drug addiction
  • E. Nestler
  • Biology, Psychology
    Neuropharmacology
  • 2014
In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism
TLDR
Prenatal undernutrition can compromise male germline epigenetic reprogramming and thus permanently alter DNA methylation in the sperm of adult offspring at regions resistant to zygotic reprograming, as well as contribute to the intergenerational transmission of environmentally induced disease.
Epigenetics of Stress-Related Psychiatric Disorders and Gene × Environment Interactions
...
...