Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution

  title={Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution},
  author={Eva Jablonka and Gal Raz},
  journal={The Quarterly Review of Biology},
  pages={131 - 176}
  • E. JablonkaG. Raz
  • Published 1 June 2009
  • Biology, Psychology
  • The Quarterly Review of Biology
This review describes new developments in the study of transgenerational epigenetic inheritance, a component of epigenetics. We start by examining the basic concepts of the field and the mechanisms that underlie epigenetic inheritance. We present a comprehensive review of transgenerational cellular epigenetic inheritance among different taxa in the form of a table, and discuss the data contained therein. The analysis of these data shows that epigenetic inheritance is ubiquitous and suggests… 

Historical perspective of transgenerational epigenetics

  • D. Ho
  • Biology
    Transgenerational Epigenetics
  • 2019

The evolutionary implications of epigenetic inheritance

It is argued that the many evolutionary consequences of epigenetic inheritance open up new research areas and require the extension of the evolutionary synthesis beyond the current neo-Darwinian model.

Epigenetic variation: origin and transgenerational inheritance.

Epigenetics and inheritance of phenotype variation in livestock

Examples of epigenetic mechanisms governing animal phenotype and behaviour, and the importance of these findings in respect to animal studies, and livestock in general, are reviewed.

Three epigenetic information channels and their different roles in evolution

It is shown that epigenetic mechanisms can serve two fundamentally different functions in transgenerational inheritance: (i) selection‐based effects, which carry adaptive information in virtue of selection over many generations of reliable transmission; and (ii) detection‐basedeffects, which are a transgenerations form of adaptive phenotypic plasticity.

Nongenetic inheritance and transgenerational epigenetics.

  • M. Szyf
  • Biology, Psychology
    Trends in molecular medicine
  • 2015

Epigenetics and transgenerational transfer: a physiological perspective

How the concepts of epigenetics and maternal effects both overlap with, and are distinct from, each other are discussed and a construct by which to integrate these concepts into the design of future investigations in animal physiology is offered.

Transgenerational epigenetic inheritance in birds

Recent advances in transgenerational epigenetics in birds are presented, which involve germline linked non-Mendelian inheritance, underline the advantages and drawbacks of working on birds in this field and comment on future directions of transgenerations studies in bird species.



The Changing Concept of Epigenetics

Recognizing that there are epigenetic inheritance systems through which non‐DNA variations can be transmitted in cell and organismal lineages broadens the concept of heredity and challenges the widely accepted gene‐centered neo‐Darwinian version of Darwinism.

Modifiers of epigenetic reprogramming show paternal effects in the mouse

Paternal effects of this type have not been reported previously in mammals and suggest that the untransmitted genotype of male parents can influence the phenotype of their offspring.

Epigenetics and plant evolution.

An introduction to epigenetic mechanisms in plants is provided, and some of the empirical studies illustrative of the possible connections between evolution and epigenetically mediated alterations in gene expression and morphology are highlighted.

Epigenetics and twins: three variations on the theme.

The evolution of the peculiarities of mammalian sex chromosomes: an epigenetic view.

  • E. Jablonka
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2004
In most discussions of the evolution of sex chromosomes, it is presumed that the morphological differences between the X and Y were initiated by genetic changes. An alternative possibility is that,

The inheritance of acquired epigenetic variations.

Epigenetics for ecologists.

Ecologists should start using a combination of experimental approaches borrowed from ecological genetics, novel techniques to analyse and manipulate epigenetic variation, and genomic tools, to investigate the extent and structure of epigenetics variation within and among natural populations, as well as the interrelations between epigenetic variations, phenotypic variation and ecological interactions.

Mechanisms of epigenetic inheritance.