Transgene-mediated Expression of Tumor Necrosis Factor Soluble Receptor Attenuates Morphine Tolerance in Rats

Abstract

Opiate/narcotic analgesics are the most effective treatments for chronic severe pain, but their clinical utility is often hampered by the development of analgesic tolerance. Recent evidence suggests chronic morphine may activate glial cells to release proinflammatory cytokines. In this study, we used herpes simplex virus (HSV) vector-based gene transfer to… (More)
DOI: 10.1038/gt.2011.76

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