Transgene expression of biological active recombinant human granulocyte-colony stimulating factor (hG-CSF) into mouse urine.

Abstract

We have generated transgenic mice that expressed human granulocyte-colony stimulating factor (hG-CSF) in their urine. In particular, the expression plasmid DNA containing mouse uroplakin II promoter was used to direct the uroepithelium-specific transcription of the transgene. In this study, the hG-CSF transcript was detected only in bladder, as was… (More)

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