Transgene expression and differentiation of baculovirus-transduced human mesenchymal stem cells.

@article{Ho2005TransgeneEA,
  title={Transgene expression and differentiation of baculovirus-transduced human mesenchymal stem cells.},
  author={Y Ho and Y C Chung and Shiaw-Min Hwang and Kuei-Chun Wang and Yu-Chen Hu},
  journal={The journal of gene medicine},
  year={2005},
  volume={7 7},
  pages={860-8}
}
BACKGROUND Mesenchymal stem cells (MSCs) have drawn considerable attention as vehicles for cell- or gene-based therapies, yet various problems still exist for current gene delivery vectors. On the other hand, baculovirus has emerged as a novel gene therapy vector, but its transduction of stem cells has not been reported. METHODS A recombinant baculovirus expressing the enhanced green fluorescent protein (EGFP) was constructed to transduce human MSCs derived from umbilical cord blood (uMSCs… CONTINUE READING
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