Transfusion transmission of retroviruses: human T‐lymphotropic virus types I and II compared with human immunodeficiency virus type 1

  title={Transfusion transmission of retroviruses: human T‐lymphotropic virus types I and II compared with human immunodeficiency virus type 1},
  author={Elizabeth Donegan and H. H. Lee and Eva A. Operskalski and George M. Shaw and Steven H. Kleinman and Michael P. Busch and Cladd E. Stevens and Eugene R Schiff and Marek J. Nowicki and Charles G. Hollingsworth and James W. Mosley},
Background: The incidence of transfusion transmission of human T‐ lymphotropic virus type I (HTLV‐I) and HTLV type II (HTLV‐II) has not been compared directly or to that of human immunodeficiency virus type 1 (HIV‐1). The effects of refrigerator storage of the blood component on infectivity of the viruses needs definition. 

Retroviruses and Associated Diseases in Humans

Retroviruses and associated diseases in humans; human T-cell leukemia virus (HTLV); long terminal repeats (LTR); reverse transcriptase (RT); and tax response element 1 (TRE-1).

Transfusion-transmitted retrovirus infection.

Blood safety strategies for human T‐cell lymphotropic virus in Europe

This work has shown that leucoreduction of blood components has been implemented to preclude the transmission of infectious agents present in white blood cells.

Human T‐lymphotropic virus type 1 infection and solid organ transplantation

  • G. Taylor
  • Medicine, Biology
    Reviews in medical virology
  • 2018
There is insufficient evidence to confirm whether these occur more frequently as a result of the associated immunosuppression, but pre‐existing HTLV‐1 infection should not be considered a contra‐indication to transplantation.

High prevalence of human T‐cell leukemia virus type‐1b genotype among blood donors in Gabon, Central Africa

The African continent is considered to be the largest endemic area of HTLV‐1 infection, with at least several million infected individuals. Systematic screening of blood donors can prevent the

Seroprevalence of human T‐lymphotropic virus (HTLV) in blood donors in sub‐Saharan Africa: a systematic review and meta‐analysis

The aim of this review is to establish the prevalence of HTLV‐1 and HTLV-1/2 among blood donors in sub‐Saharan Africa.

Epidemiology of human T-lymphotropic virus type II (HTLV-II) infection in Spain

HTLV-II infection is present in Spain, mainly among IDUs, with a growing incidence and a current overall prevalence of 2.0 percent, according to a survey of 113 individuals identified up to September 1995.

Human T‐lymphotropic virus and transfusion safety: does one size fit all?

Human T‐cell leukemia viruses (HTLV‐1 and HTLV‐2) are associated with a variety of human diseases, including some severe ones. Transfusion transmission of HTLV through cellular blood components is

Human T‐Cell Lymphotrophic Virus Infection in Organ Donors: A Need to Reassess Policy?

  • B. ShamesA. D’ALESSANDROH. Sollinger
  • Medicine, Biology
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2002
It is recommended that careful consideration be given to transplanting organs from HTLV‐I/II‐positive organ donors, and the minimal chance ofHTLV‐related disease following transplantation of HTLV-I/ II organs in this series is recommended.

Effectiveness of human T‐lymphotropic virus (HTLV) recipient tracing (lookback) and the current HTLV‐I and ‐II confirmatory algorithm, 1999 to 2004

BACKGROUND:  This study reports on the efficacy of an investigational human T‐lymphotropic virus (HTLV)‐I and ‐II lookback program in the context of differing confirmatory testing algorithms.



Transmission of human T‐lymphotrophic virus type I infection to a neonatal infant by transfusion of washed and irradiated red cells

Human T‐lymphotropic virus type I and/or II (HTLV‐I/II) may be transmitted by the transfusion of blood and blood components. Several factors are critical to the efficiency of transmission. These

Transmission of HTLV‐II via Blood Transfusion

There is a growing body of evidence that a substantial proportion of HTLV‐I/II seropositivity in the US is due to infection withHTLV‐II, and the importance of distinguishing between the two viruses in blood donors and recipients is discussed.

Transfusion transmission of human T‐lymphotropic virus types I and II: serologic and polymerase chain reaction results in recipients identified through look‐back investigations

It appears that some HTLV‐II‐infected transfusion recipients will not be detected by existingHTLV‐I antigen‐based reagents, and it is suggested that the current testing algorithm be modified in selected cases.

Epidemiologic background of blood donors with antibody to human T‐cell lymphotropic virus

These results show a broader variation of epidemiologic backgrounds than anticipated, and the most common characteristic was an association with Japan or the Caribbean basin.

Transmission of human T‐lymphotropic virus type I by blood components from a donor lacking anti‐p24: a case report

A blood donor was anti‐HTLV‐I/II positive on enzyme‐linked immunoassay, and two sera taken 5 years apart were WB/RIPA‐ indeterminate (p19 and gp68 only), his donations in the interval were associated with transmission of HTLV‐ I to four of the six recipients available for study.

Transmission of human T-lymphotropic virus types I and II by blood transfusion. A retrospective study of recipients of blood components (1983 through 1988). The American Red Cross HTLV-I/II Collaborative Study Group.

It is concluded that transfusion transmission of HTLV-I/II to approximately 700 recipients per year occurred in the United States before routine donor testing began in 1988.

Infection with human immunodeficiency virus type 1 (HIV-1) among recipients of antibody-positive blood donations.

Transfusion of anti-HIV-1-positive blood infected 90% of recipients and the rate of progression to AIDS within the first 38 months after infection was similar to that reported for homosexual men and hemophiliacs.

A Retrospective Study on Transmission of Adult T Cell Leukemia Virus by Blood Transfusion: Seroconversion in Recipients

The development of anti-ATLA in the recipients may correspond to antibody production after establishment of primary infection with ATLV that is associated with cells in blood from anti‐ATLA‐positive donors who are ATLV carriers.

Evaluation of human T cell lymphotropic virus infection in a cohort of injecting drug users.

A high rate (22.3%) of HTLV reactivity, with HTLV-II usually the sole responsible agent; shortcomings in standard HT LV-I-based diagnostics but usefulness of PCR and p21 envr Western blots for typing and confirmation of HT LV reactivity; and a high prevalence of anti-tax antibody among HTLV -II-seropositive subjects, suggesting increased potential for infectivity.

Transmission of HTLV-I by blood transfusion and its prevention by passive immunization in rabbits.

The results indicate that HTLV-I can be transmitted with as little as 0.01 mL of virus-infected blood, and that passive immunization is effective in preventing cell-to-cell infection of HTLV -I when given within 24 hours of transfusion of HIV- infected blood.