Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial.

@article{Holcomb2015TransfusionOP,
  title={Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial.},
  author={John B. Holcomb and Barbara C. Tilley and Sarah Baraniuk and Erin E. Fox and Charles E. Wade and Jeanette M. Podbielski and Deborah J. del Junco and Karen J. Brasel and Eileen M. Bulger and Rachael A Callcut and Mitchell Jay Cohen and Bryan A. Cotton and Timothy C. Fabian and Kenji Inaba and Jeffrey D Kerby and Peter C Muskat and Terence S O'Keeffe and Sandro Rizoli and Bryce R. H. Robinson and Thomas M. Scalea and Martin Schreiber and Deborah M. Stein and Jordan A. Weinberg and Jeannie L Callum and John R Hess and Nena Matijevic and Christopher Miller and J F Pittet and David Butler Hoyt and Gail Denise Pearson and Brian G Leroux and Gerald van Belle},
  journal={JAMA},
  year={2015},
  volume={313 5},
  pages={471-82}
}
IMPORTANCE Severely injured patients experiencing hemorrhagic shock often require massive transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red blood cells), defined as damage control resuscitation, has been associated with improved outcomes; however, there have been no large multicenter clinical trials. OBJECTIVE To determine the effectiveness and safety of transfusing patients with severe trauma and major bleeding using plasma, platelets, and red… CONTINUE READING

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