Transfusion-associated graft-versus-host disease: risk due to homozygous HLA haplotypes.

@article{Wagner1995TransfusionassociatedGD,
  title={Transfusion-associated graft-versus-host disease: risk due to homozygous HLA haplotypes.},
  author={Franziska Wagner and Willy Albert Flegel},
  journal={Transfusion},
  year={1995},
  volume={35 4},
  pages={
          284-91
        }
}
BACKGROUND Transfusion-associated graft-versus-host disease (TA-GVHD) may occur in transfusions of blood from HLA-homozygous persons to HLA-heterozygous persons who share a haplotype. STUDY DESIGN AND METHODS Two mathematical models were developed to calculate the upper and lower limit of the associated risks in various populations using a combination of serology- and DNA sequence-based HLA haplotype frequencies. RESULTS For nondirected transfusion, the range of the estimated risk in United… CONTINUE READING
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