Transfusion-associated graft-versus-host disease: current concepts and future trends.

  title={Transfusion-associated graft-versus-host disease: current concepts and future trends.},
  author={M J Seghatchian and Fereydoun Ala},
  journal={Transfusion science},
  volume={16 2},
Since the initial reports, in the early 1960s, of Transfusion-Associated Graft-versus-Host Disease (TA-GVHD) in infants with congenital immunodeficiency and individuals with various haematological malignancies, our knowledge of this rare but uniformly fatal consequence of transfusion has improved. Today, it is possible to define with greater certainty patients who are most at risk; the blood components capable of causing TA-GVHD; and the methods for preventing TA-GVHD. In the absence of… CONTINUE READING