Transfusion and Alloimmunization in Sickle Cell Disease

  title={Transfusion and Alloimmunization in Sickle Cell Disease},
  author={Wendell and Rosse and Dianne Gallagher and Thomas R. Kinney and Oswaldo de Castro and Harvey Dosik and John W Moohr and Winfred C. Wang and Paul S. Levy},
In 1,814 patients with sickle cell disease who had been transfused, the overall rate of alloimmunization to erythrocyte antigens was 18.6%. The rate of alloimmunization in this group appears to be an explicit function of the number of transfusions received because it increases exponentially with increasing numbers of transfusions. Alloimmunization usually occurred with less than 15 transfusions, although the rate of alloimmunization continued to increase when more transfusions were given. The… CONTINUE READING


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Brozovic: Red cell alloimmunization in sickle cell disease

SC Davies, AC McWillam, PE Hewitt, A Devenish
Br J Haematol • 1986

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