Transforming men into mice: the Nadeau-Taylor chromosomal breakage model revisited

  title={Transforming men into mice: the Nadeau-Taylor chromosomal breakage model revisited},
  author={Pavel A. Pevzner and Glenn Tesler},
Although analysis of genome rearrangements was pioneered by Dobzhansky and Sturtevant 65 years ago, we still know very little about the rearrangement events that produced the existing varieties of genomic architectures. The genomic sequences of human and mouse provide evidence for a larger number of rearrangements than previously thought and shed some light on previously unknown features of mammalian evolution. In particular, they reveal extensive re-use of breakpoints from the same relatively… CONTINUE READING

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