Transforming growth factor type beta specifically stimulates synthesis of proteoglycan in human adult arterial smooth muscle cells.

@article{Chen1987TransformingGF,
  title={Transforming growth factor type beta specifically stimulates synthesis of proteoglycan in human adult arterial smooth muscle cells.},
  author={James K Chen and Hiroyoshi Hoshi and Wallace L. Mckeehan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 15},
  pages={
          5287-91
        }
}
Myo-intimal proteoglycan metabolism is thought to be important in blood vessel homeostasis, blood clotting, atherogenesis, and atherosclerosis. Human platelet-derived transforming growth factor type beta (TGF-beta) specifically stimulated synthesis of at least two types of chondroitin sulfate proteoglycans in nonproliferating human adult arterial smooth muscle cells in culture. Stimulation of smooth muscle cell proteoglycan synthesis by smooth muscle cell growth promoters (epidermal growth… CONTINUE READING
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