Transforming growth factor type beta regulation of actin mRNA.


Stimulation of quiescent cultures of AKR-2B cells with transforming growth factor type beta (TGF beta) resulted in a transitory increase in actin cytoplasmic poly(A) + RNA. Levels of actin mRNA peaked approximately 4-8 hours subsequent to TGF beta addition and approached basal levels by 24 hours. The accumulation of actin transcripts was dose dependent and insensitive to inhibitors of protein synthesis; 1-3 ng/ml TGF beta induced maximal actin gene expression. Actin isotype-specific probes demonstrated that both beta- and gamma-cytoplasmic actins are induced by TGF beta.


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@article{Leof1986TransformingGF, title={Transforming growth factor type beta regulation of actin mRNA.}, author={Edward B. Leof and Jacqueline A. Proper and Michael J. Getz and Harold L . Moses}, journal={Journal of cellular physiology}, year={1986}, volume={127 1}, pages={83-8} }