• Medicine
  • Published in
    Orthodontics & craniofacial…
    2002

Transforming growth factor-beta3 (Tgf-beta3) down-regulates Tgf-beta3 receptor type I (Tbetar-I) during rescue of cranial sutures from osseous obliteration.

@article{Opperman2002TransformingGF,
  title={Transforming growth factor-beta3 (Tgf-beta3) down-regulates Tgf-beta3 receptor type I (Tbetar-I) during rescue of cranial sutures from osseous obliteration.},
  author={Lynne A. Opperman and V Galanis and Alistair RW Williams and Katayoun Adab},
  journal={Orthodontics & craniofacial research},
  year={2002},
  volume={5 1},
  pages={
          5-16
        }
}
Appropriate biochemical regulation of intramembranous bone growth from sutures is necessary to achieve correct craniofacial morphology. Failure to form sutures (agenesis) or to maintain sutures in their unossified state (craniosynostosis) can result in severe facial dysmorphology. Several factors such as Twist, Msx2, fibroblast growth factors (Fgfs), bone morphogenetic proteins (Bmps) and transforming growth factors-beta (Tgf-betas) regulate suture patency, likely by interacting with one… CONTINUE READING