Transforming growth factor-beta2 is elevated in skeletal muscle disorders.

@article{Murakami1999TransformingGF,
  title={Transforming growth factor-beta2 is elevated in skeletal muscle disorders.},
  author={Nobutoshi Murakami and Ian S McLennan and Ikuya Nonaka and Kyoko Koishi and Cathy Baker and Graeme Hammond-Tooke},
  journal={Muscle & nerve},
  year={1999},
  volume={22 7},
  pages={889-98}
}
The transforming growth factor betas (TGF-betas) are multifunctional growth factors that act on both fibroblasts and myosatellite cells. In rodent models of muscle diseases, high levels of TGF-beta2 are expressed by myogenic cells. We have examined whether the expression of TGF-beta2 is also elevated in diseased human muscles. The disorders examined were Duchenne muscular dystrophy, myotonic dystrophy, myotubular myopathy, spinal muscular atrophy, and amyotrophic lateral sclerosis. The levels… CONTINUE READING
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