Transforming growth factor-beta2 is elevated in skeletal muscle disorders.

  title={Transforming growth factor-beta2 is elevated in skeletal muscle disorders.},
  author={Nobutoshi Murakami and Ian S McLennan and Ikuya Nonaka and Kyoko Koishi and Cathy Baker and Graeme Hammond-Tooke},
  journal={Muscle & nerve},
  volume={22 7},
The transforming growth factor betas (TGF-betas) are multifunctional growth factors that act on both fibroblasts and myosatellite cells. In rodent models of muscle diseases, high levels of TGF-beta2 are expressed by myogenic cells. We have examined whether the expression of TGF-beta2 is also elevated in diseased human muscles. The disorders examined were Duchenne muscular dystrophy, myotonic dystrophy, myotubular myopathy, spinal muscular atrophy, and amyotrophic lateral sclerosis. The levels… CONTINUE READING
14 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…