Transforming growth factor-beta1 stimulates collagen matrix remodeling through increased adhesive and contractive potential by human renal fibroblasts.

@article{Kondo2004TransformingGF,
  title={Transforming growth factor-beta1 stimulates collagen matrix remodeling through increased adhesive and contractive potential by human renal fibroblasts.},
  author={Shuji Kondo and Shoji Kagami and Maki Urushihara and Akiko Kitamura and Maki Shimizu and Frank Strutz and Gerhard A. M{\"u}ller and Yasuhiro Kuroda},
  journal={Biochimica et biophysica acta},
  year={2004},
  volume={1693 2},
  pages={91-100}
}
Renal tubulointerstitial fibrosis is the common final pathway leading to end-stage renal failure. Tubulointerstitial fibrosis is characterized by fibroblast proliferation and excessive matrix accumulation. Transforming growth factor-beta1 (TGF-beta1) has been implicated in the development of renal fibrosis accompanied by alpha-smooth muscle actin (alpha-SMA) expression in renal fibroblasts. To investigate the molecular and cellular mechanisms involved in tubulointerstitial fibrosis, we examined… CONTINUE READING

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