Transforming growth factor-beta1 promotes the morphological and functional differentiation of the myofibroblast.

  title={Transforming growth factor-beta1 promotes the morphological and functional differentiation of the myofibroblast.},
  author={Melville B Vaughan and Eric W. Howard and James J. Tomasek},
  journal={Experimental cell research},
  volume={257 1},
The myofibroblast is responsible for the generation of contractile force associated with wound contraction and pathological contractures and is characterized by the presence of alpha-smooth muscle (alpha-sm) actin-containing stress fibers, vinculin-containing fibronexus adhesion complexes, and fibronectin fibrils containing the ED-A splice variant. Transforming growth factor-beta1 (TGF-beta1) can promote the expression of alpha-sm actin in myofibroblasts, but the functional significance of this… 

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