Transforming growth factor beta1 inhibits steroidogenesis in dispersed fetal testicular cells in culture.

@article{Gautier1997TransformingGF,
  title={Transforming growth factor beta1 inhibits steroidogenesis in dispersed fetal testicular cells in culture.},
  author={Claude Gautier and Christine Levacher and Jos{\'e} S{\'a}ez and Ren{\'e} Habert},
  journal={Molecular and cellular endocrinology},
  year={1997},
  volume={131 1},
  pages={21-30}
}
TGF beta1 has been detected by immunohistochemistry in the rat fetal testis. Therefore, we attempted to determine whether this factor can act as a local regulator of Leydig cell function during fetal development. An inhibitory effect of TGF beta1 on basal and luteinizing hormone (LH)-stimulated testosterone secretion by fetal testes in vitro was observed only with testes from 13.5 day-old fetuses and not with testes from older stages. The lack of effect of exogenous TGF beta1 in organ culture… CONTINUE READING

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