Transforming growth factor beta1 expression and activation is increased in the alcoholic rat lung.

@article{Bechara2004TransformingGF,
  title={Transforming growth factor beta1 expression and activation is increased in the alcoholic rat lung.},
  author={Rabih I Bechara and Lou Ann Scism Brown and Jesse Roman and Pratibha C Joshi and David M. Guidot},
  journal={American journal of respiratory and critical care medicine},
  year={2004},
  volume={170 2},
  pages={188-94}
}
Alcohol abuse increases the incidence of acute respiratory distress syndrome more than threefold in patients with septic shock. We have shown that chronic ethanol ingestion in a rat model impairs alveolar epithelial barrier function and enhances lung injury during sepsis. We speculated that transforming growth factor beta(1) (TGFbeta(1)), a pluripotent cytokine implicated in models of epithelial barrier disruption and lung injury, could mediate alveolar epithelial injury in the alcoholic lung… CONTINUE READING

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