Transforming growth factor beta1 decreases cholesterol supply to mitochondria via repression of steroidogenic acute regulatory protein expression.

@article{Brand1998TransformingGF,
  title={Transforming growth factor beta1 decreases cholesterol supply to mitochondria via repression of steroidogenic acute regulatory protein expression.},
  author={Christopher Brand and Nadia Cherradi and Genevi{\`e}ve Defaye and Alana Chinn and Edmond M. Chambaz and J J Feige and Sabine Bailly},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 11},
  pages={6410-6}
}
Transforming growth factor-betas (TGF-betas) constitute a family of dimeric proteins that affect growth and differentiation of many cell types. TGF-beta1 has also been proposed to be an autocrine regulator of adrenocortical steroidogenesis, acting mainly by decreasing the expression of cytochrome P450c17. Here, we demonstrate that TGF-beta1 has a second target in bovine adrenocortical cells, namely the steroidogenic acute regulatory protein (StAR). Indeed, supplying cells with steroid… CONTINUE READING

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