Transforming growth factor beta stimulates the expression of fibronectin and of both subunits of the human fibronectin receptor by cultured human lung fibroblasts.

@article{Roberts1988TransformingGF,
  title={Transforming growth factor beta stimulates the expression of fibronectin and of both subunits of the human fibronectin receptor by cultured human lung fibroblasts.},
  author={C J Roberts and T M Birkenmeier and Jeff McQuillan and Steven K. Akiyama and Susan S. Yamada and W. T. Chen and Kenneth M Yamada and John Alan McDonald},
  journal={The Journal of biological chemistry},
  year={1988},
  volume={263 10},
  pages={4586-92}
}
Transforming growth factors of the beta-class (TGFs-beta) stimulate extracellular matrix synthesis and have been implicated in embryogenesis, wound healing, and fibroproliferative responses to tissue injury. Because cells communicate with several extracellular matrix components via specific cell membrane receptors, we hypothesized that TGFs-beta may also regulate the expression of such receptors. We confirmed that TGF-beta 1 increases the expression of fibronectin, an adhesive glycoprotein… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 60 extracted citations

Similar Papers

Loading similar papers…