Transforming growth factor-beta stimulates alpha 2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site.

@article{Inagaki1994TransformingGF,
  title={Transforming growth factor-beta stimulates alpha 2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site.},
  author={Yutaka Inagaki and Susarah J. Truter and Fernando Rivadeneira Ramirez},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 20},
  pages={
          14828-34
        }
}
Transforming growth factor-beta 1 (TGF-beta) is a strong and rapid inducer of several genes coding for extracellular matrix components, such as type I collagen. We report here that TGF-beta stimulates transcription of the human alpha 2(I) collagen gene (COL1A2) promoter by increasing the affinity of an Sp1-containing protein complex for its cognate DNA-binding site. Cell transfection experiments mapped the TGF-beta-responsive element (TbRE) of the COL1A2 promoter to a 131 bp region that… CONTINUE READING

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