Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.

@article{Jin2004TransformingGF,
  title={Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.},
  author={Y Jin and Eun-Joo Jeon and Qing-lin Li and Yong Hee Lee and Jungmin Choi and W. -G. Kim and Kwang Youl Lee and S C Bae},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 28},
  pages={29409-17}
}
The Runt domain transcription factors (RUNXs) play essential roles in normal development and neoplasias. Genetic analyses of animals and humans have revealed the involvement of RUNX1 in hematopoiesis and leukemia, RUNX2 in osteogenesis and cleidocranial dysplasia, and RUNX3 in the development of T-cells and dorsal root ganglion neurons and in the genesis of gastric cancer. Here we report that RUNX3 is a target of the acetyltransferase activity of p300. The p300-dependent acetylation of three… CONTINUE READING

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