Transforming growth factor-beta-stimulated endocardial cell transformation is dependent on Par6c regulation of RhoA.

@article{Townsend2008TransformingGF,
  title={Transforming growth factor-beta-stimulated endocardial cell transformation is dependent on Par6c regulation of RhoA.},
  author={Todd A Townsend and Jeffrey L. Wrana and George E Davis and Joey V. Barnett},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 20},
  pages={13834-41}
}
Valvular heart disease due to congenital abnormalities or pathology is a major cause of mortality and morbidity. Understanding the cellular processes and molecules that regulate valve formation and remodeling is required to develop effective therapies. In the developing heart, epithelial-mesenchymal transformation (EMT) in a subpopulation of endocardial cells in the atrioventricular cushion (AVC) is an important step in valve formation. Transforming growth factor-beta (TGFbeta) has been shown… CONTINUE READING
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