Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation.

@article{Verrecchia2002TransformingGF,
  title={Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation.},
  author={Franck Verrecchia and Alain Mauviel},
  journal={The Journal of investigative dermatology},
  year={2002},
  volume={118 2},
  pages={211-5}
}
Transforming growth factor (TGF)-beta represents a prototype of multifunctional cytokine. Its broad activities include, among others, context-specific inhibition or stimulation of cell proliferation, control of extracellular matrix (ECM) synthesis and degradation, control of mesenchymal-epithelial interactions during embryogenesis, mediation of cell and tissue responses to injury, control of carcinogenesis, and modulation of immune functions. Regulation of production and turnover of ECM… CONTINUE READING

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