Transforming growth factor-beta signaling pathway in patients with Kawasaki disease.

  title={Transforming growth factor-beta signaling pathway in patients with Kawasaki disease.},
  author={Chisato Shimizu and Sonia Jain and Sonia D{\'a}vila and Martin L. Hibberd and Kevin O. Lin and Delaram Pour Molkara and Jeffrey R. Frazer and Shelly Sun and Annette L. Baker and Jane W. Newburger and Anne H. Rowley and Stanford T. Shulman and David Burgner and Willemijn B. Breunis and Taco Willem Kuijpers and Victoria J. Wright and Michael Levin and Hariklia Eleftherohorinou and Lachlan Coin and Stephen J Popper and David A. Relman and Wen Fury and Calvin Lin and Scott J Mellis and Adriana H. Tremoulet and Jane C. Burns},
  journal={Circulation. Cardiovascular genetics},
  volume={4 1},
BACKGROUND Transforming growth factor (TGF)-β is a multifunctional peptide that is important in T-cell activation and cardiovascular remodeling, both of which are important features of Kawasaki disease (KD). We postulated that variation in TGF-β signaling might be important in KD susceptibility and disease outcome. METHODS AND RESULTS We investigated genetic variation in 15 genes belonging to the TGF-β pathway in a total of 771 KD subjects of mainly European descent from the United States… CONTINUE READING
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