Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis.

@article{Siegel2003TransformingGF,
  title={Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis.},
  author={Peter M Siegel and Weiping Shu and Robert Cardiff and William J. Muller and Joan Massagu{\'e}},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 14},
  pages={8430-5}
}
The influence of transforming growth factor beta (TGF-beta) signaling on Neu-induced mammary tumorigenesis and metastasis was examined with transgenic mouse models. We generated mice expressing an activated TGF-beta type I receptor or dominant negative TGF-beta type II receptor under control of the mouse mammary tumor virus promoter. When crossed with mice expressing activated forms of the Neu receptor tyrosine kinase that selectively couple to the Grb2 or Shc signaling pathways the activated… CONTINUE READING
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