Transforming growth factor beta signal transduction: a potential target for maintenance/restoration of transparency of the cornea.

@article{Saika2010TransformingGF,
  title={Transforming growth factor beta signal transduction: a potential target for maintenance/restoration of transparency of the cornea.},
  author={Shizuya Saika and Osamu Yamanaka and Takayoshi Sumioka and Yuka Okada and Takeshi Miyamoto and Kumi Shirai and Ai Kitano and Sai-ichi Tanaka},
  journal={Eye & contact lens},
  year={2010},
  volume={36 5},
  pages={286-9}
}
Maintenance of the transparency and regular shape of the cornea are essential to the normal vision, whereas opacification of the tissue impairs vision. Fibrogenic reaction leading to scarring in an injured cornea is characterized by appearance of myofibroblasts, the key player of the fibrogenic reaction, and excess accumulation of fibrous extracellular matrix. Inflammatory/fibrogenic growth factors/cytokines produced by inflammatory cells play a pivotal role in fibrogenic response. Signaling… CONTINUE READING

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