Transforming growth factor-beta selectively inhibits branching morphogenesis but not tubulogenesis.

@article{Sakurai1997TransformingGF,
  title={Transforming growth factor-beta selectively inhibits branching morphogenesis but not tubulogenesis.},
  author={Hiroyuki Sakurai and Sanjay K. Nigam},
  journal={The American journal of physiology},
  year={1997},
  volume={272 1 Pt 2},
  pages={F139-46}
}
When cultured in type I collagen gels, two kidney-derived cell lines, Madin-Darby canine kidney (MDCK) cells and murine inner medullary collecting duct (mIMCD3) cells, from branching tubular structures in the presence of Swiss 3T3 conditioned medium, in which hepatocyte growth factor (HGF) is the major branching tubule inducing factor. However, upon incubation with transforming growth factor-beta (TGF-beta) in the presence of 3T3 conditioned medium, MDCK tubulogenesis and branching was markedly… CONTINUE READING

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