Transforming growth factor beta regulates clusterin gene expression via modulation of transcription factor c-Fos.

@article{Jin1999TransformingGF,
  title={Transforming growth factor beta regulates clusterin gene expression via modulation of transcription factor c-Fos.},
  author={G Jin and Philip H Howe},
  journal={European journal of biochemistry},
  year={1999},
  volume={263 2},
  pages={534-42}
}
Transforming growth factor-beta (TGFbeta) induces gene expression of the glycoprotein clusterin in a variety of cell types via a consensus AP-1 binding site. Here, we demonstrate, by supershift analysis, that JunB, JunD, Fra1, Fra2, and c-Fos bound to AP-1 but that prior treatment of the cells with TGFbeta reduced dramatically c-Fos binding, suggesting that c-Fos might be playing a negative regulatory role in clusterin gene expression. Transient cotransfection assays in mink lung epithelial… CONTINUE READING
17 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…